60 MHz 1H NMR Reaction Monitoring |
Below are a few further examples of acetylation reactions of acetic
anhydride with an excess of alcohol. The alcohols include tert-butanol and
isopropanol.
Reaction 1: Acetylation of t-butyl alcohol with acetic anhydride in the presence of acid. |
Reaction 2: Acetylation of Isopropanol
with acetic
anhydride in the presence of acid.
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Reaction 3: Methoxyacetone and hydroxylamine reaction in methanol to form an
Oxime
|
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Resolution of the methylenes in the methoxyacetone and the reaction product
is readily observed.
 |
All the above experiments were performed in an NMR tube. We are currently
looking at the same reactions under flow conditions utilizing a HPLC pump
and PEEK tubing to transport sample to the NMR probe at 5 ml/min.
Contact John Edwards if you have
interest in permanent magnet NMR technology for reaction monitoring. |
