An article by Dr. John Edwards of Process NMR Associates and researchers at the Southern Regional Research Center of the US Department of Agriculture (Dr. H.N. Cheng, Lynda H. Wartelle, K. Thomas Klasson) has been accepted for publication in the Elsevier Journal Carbon. The paper entitled "Solid state NMR and ESR studies of activated carbons produced from pecan shells" is available at the following link: Carbon Paper . Process NMR Associates provided the solid-state 13C NMR, TD-NMR, and ESR spectroscopy for the analysis of the activated carbons derived from pecan shells.
We are currently developing a spinner system for the process NMR system in order to improve spectral resolution sufficiently to quantify omega-3 fatty acids in fish oils. The omega-3 fatty acid methyl group can be discerned in the 1H spectra currently produced by the spectrometer but improvement can be made with sample spinning which will improve the quantitation.
It was announced this week that the ACD NMR Processor Academic Edition is freely available for non-commercial use and can be downloaded from the ACD Website. Other Windows based NMR processing software packages are available and here is a listing of where they can be downloaded: 1) SpinWorks - written by Kirk Marat at the University of Manitoba - Download Here 2) GSim - written by Vadim Zorin Download Here 3) RNMR (Requires R Statistical Freeware Package) - Download Here - R Software can be obtained here 4) MatNMR (Requires MATLAB) - Download Here 5) Hires - Download Here
John Edwards and Paul Giammatteo of Process NMR Associates have written a chapter "Process NMR Spectroscopy: Technology and On-Line Applications" to appear in the 2nd Edition of "Process Analytical Technology" published by Wiley and Sons and Edited by Katherine Bakeev. The book will be published in May 2010 and is available for pre-order.
Digital Spectrometers based on field programmable gate arrays will soon change the face of NMR spectroscopy as a routine use analytical instrument. Stan Sykora in his excellent blog (http://www.ebyte.it/stan/blog07.html#07jun14) describes how the transition of NMR spectrometers to digital electronics has drastically reduced the footprint and price of NMR spectrometers and increased the potential complexity of the RF synthesis as well as the NMR post processing on the same chip. In fact single chips can hold multiple spectrometers enabling the building of single spectrometers that can perform experiments on multiple magnet systems. One of the best journal articles on the topic is by Kazuyuki Takeda "OPENCORE NMR: Open-source core modules for implementing an integrated FPGA-based NMR spectrometer", Journal of Magnetic Resonance, 192(2), 218-229, 2008. This gentleman also included all the core modules, console software, pulse programs and board designs required to build your own spectrometer (see Opencore Website). The availability of superconducting NMR magnets are still the barrier to entry for cheaper high field NMR systems but in the lower field NMR area these spectrometers will enable a drastic reduction in instrumentation cost and perhaps lead to a larger NMR market. In the near future I feel that NMR systems in…
The use of an NMR as a simple flow detector for benchtop reaction monitoring, mixing monitoring, dilution monitoring, or conversion monitoring has been limited by the need to bring the
Presented here are several simple reactions monitored by 60 MHz process NMR performed in a 5 mm NMR tube. Reaction #1: Acetic Anhydride in Water - Reacts to form Acetic Acid NMR Monitored Reaction Profile Reaction #2: Acetic Anhydride + Excess of Methanol + Acid - Yields Acetic Acid and Acetic Methyl Ester First Reaction was Performed without Shaking the Sample before Observation NMR Monitored Reaction Profile Second Reaction was Performed with a vigorous shake of the NMR tube before observation. NMR Monitored Reaction Profile For More Information Contact John Edwards
These are non-spinning spectra obtained on a Qualion process NMR spectrometer operating at 58 MHz. The spec on water at this shim level is 1.5/5/20 Hz at 50%/10%/0.5% peak height. The first spectrum is of 91% isopropyl alcohol in water - store bought pharmacy product. The second spectrum shows the comparison of a 300 MHz 1H NMR spectrum of Advil compared to a non-spinning 58 MHz spectrum.