Solid-State 13C NMR of Drug API and Tablets

We have an excellent solid-state Doty Scientific Supersonic 7mm CP-MAS probe for our Varian UP-200 spectrometer. This is a nice field strength for solid-state 13C analyses as it allows for spectra at higher sensitivity than a 100 MHz but still has the advantage that 7 kHz is enough to push the aromatic MAS sidebands beyond 0 ppm so that more accurate aromaticity values can be calculated. The probe is still working after 20 years and we are using the original rotors and have never had to replace any of the capacitors. We have run approaching 20,000 experiments with this probe. Here are some of the nice spectra we have been getting recently on drug API and tablets.

Above: Solid-State 13C NMR of Rapamycin API

Above: Solid-State 13C NMR of Ranitidine HCl – Zantac Tablet

Above: Solid-State 13C NMR of Simvastatin 20 mg Tablet

Solid-State 13C NMR of Tylenol 3 – Acetamenaphin + Codeine

Above: Solid-State 13C NMR of Amoxicillin Capsules

Above: Solid-State 13C NMR of Diovan 50 mg Tablet

Above: Solid-State 13C NMR of Divalproex Tablet

Above: Solid-State 13C NMR of Herbal Supplement Capsule Found to Contain Thioaildenafil – A Structural Analog of Sildenafil (aka Viagra)

Above: Solid_State 13C NMR of Famotidine Tablet

Above: Solid-State 13C NMR of Metroprolol 50 mg Tablet

Above: Solid-State 13C NMR spectrumof Azithromycin Tablet

Solid-State 13C NMR of Ibuprofen – Generic 200mg Tablet