Facilities at Process NMR Associates
Liquid-State NMR Equipment
NMR Equipment Process NMR Associates (PNA) owns and operates are two Varian Mercury-300 superconducting NMR spectrometers. The computer systems comprise of Dell Precision T3500 workstations operating with Centos Linux and VNMRJ 4.2 NMR software. All computers are locally networked to the PNA intranet and cloud systems. The spectrometer probes comprise of various ATB and 4-Nucleus Varian 5 mm probes. The 4-nucleus and ATB probes area dual band probes simultaneously tuned to 1H/19F and 31P/13C and/or tuneable to X nucleus frequencies. All probes are equipped with pulsed field gradient coils for gradient experiments and shimming. Varian broadband 10mm probe for 13C and low sensitivity experiments, as well as a Nalorac 20 mm probe for short 13C experimental times. Variable temperature capabilities (ambient-120C) are also available. For a listing of possible applications see the Liquid-State NMR Applications.
Solid-State NMR Equipment
PNA also operates a solid-state Varian UnityPlus-200 NMR spectrometer and a Varian Inova-300 MHz. The solid-state 200 MHz NMR probe is a 7mm Doty Scientific Supersonic CP/MAS probe capable of observing any NMR active nucleus (excluding low gyromagnetic ratio nuclei), using either single pulse, multi-pulse, or cross- polarization in conjunction with magic angle spinning (at rates up to 13 kHz). For a listing of possible applications see the solid-state NMR applications page. A Varian 5mm broadband probe is also available if liquid-state NMR is required at this lower field. The Inova-300 system is equipped with a Varian 7mm CP-MAS probe (Jakobsen system). Solid-State NMR Applications.
Our NMR systems all utilize the Varian “R2D2” magnet – take a look inside one of these magnets – Deconstruction
High Performance Liquid-Chromatography (HPLC) Equipment
Dr. Ellie McBarkington and Dr. Bolton Kendrik-Smyth III discuss an NMR experiment with the principal.
Benchtop Permanent Magnet NMR Systems
We also house a lab containing a variety of benchtop NMR systems that are lent to us for application development purposes. If you have a particular benchtop NMR system and are interested in application automation of chemometric correlation development contact us for further details.
Process NMR Equipment
Process NMR Associates also operates several 60 MHz high-resolution process NMR units for chemometric model or laboratory application development and feasibility testing.
Permanent Magnet NMR Systems Lab – Process NMR Associates – 60 MHz HR-NMR and 20 MHz TD-NMR
Time-Domain NMR Spectrometers at 14, 16, 19.5, 20 and 25 MHz
Process NMR Associates operates a total of 3 TD-NMR spectrometers. We also operate a 10 mm Portable Spin Track TD-NMR spectrometer from resonance Systems Ltd. The Spin Track NMR also has multi frequency ability from 2 to 60 MHz and also operates an NMR surface sensor. We also operate a Cosa-Xentaur Spin-Pulse TD-NMR spectrometer at 15 MHz (40 mm sample dimension), 18 MHz (20 mm sample dimension), and 23 MHz (10 mm sample dimension).
Other Analytical Equipment – Mid-IR ATR and Simulated Distillation GC System
- FTIR-ATR: Smiths Detection IdentifyIR – PNA is under contract with Cosa-Xentaur to develop chemometric applications for the Smiths Detection FTIR-ATR platform
- Simulated Distillation GC: Shimadzu GC-2010
- Micro-ESR Spectrometer
- Petrometrix NIR Spectrometer
- Karl-Fischer Moisture Analyzer
General Laboratory Equipment
Process NMR Associates is equipped with various peripheral lab equipment to facilitate the safe and effective preparation of NMR samples in 5mm and 10 mm NMR tubes. These facilities include explosion proof refrigerator and oven, a ductless fume hood, various sample prep equipment for NMR. We have a Virtis benchtop freeze dryer for observation of low concentration components after reconsitution in D2O.
NMR and Chemistry Related Library and Software
Process NMR Associates has developed a 100+ volume NMR library containing most published NMR books and references. We also have several 1H, 13C and 31P assignment libraries for structural elucidation studies. The Sadtler C-Search software is available on the Varian-300 spectrometer, ACD H-NMR is available on PC. We have a rather extensive collection of chemistry, petroleum and petrochemical related volumes as well as an entire set ASTM standards and practices. We use Mnova 10.0, Acorn Nuts, Spinworks, and MestreC as post-processing software when necessary.
Process NMR Associates uses the following chemometrics packages for method development:
- Grams with PLS/IQ – Galactic Industries
- Pirouette – Infometrix
- Matlab with Chemometric Toolbox from Eigenvector Research
- Eigenvector Research Solo 6.5