Solid-State 13C NMR Study of Polymorphism
Solid-state 13C NMR is used extensively to study crystalline polymorphs and the relative crystalline and amorphous content of pharmaceutical excipients.
Process NMR Associates performs these studies on a dedicated Varian UnityPlus-200 spectrometer to yield spectral and relaxation data to allow the determination of drug-excipient interactions as well as simple polymorph differentiation and amorphous material content. Both 13C SP-MAS and CP-MAS experiments are utilized in these studies along with T1 and cross-relaxation time determinations.
The FDA have summarized the effects of polymorphism in pharmaceutical solids. PDF Version.
Please contact us if you have a potential polymorph project that would benefit from solid-state NMR analysis.